Multifocal motor neuropathy (MMN): invetigations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Multifocal motor neuropathy (MMN): invetigations. Axonal loss, Slow conduction velocities, Conduction block. Fully referenced neurology checklist.

Nerve conduction studies (NCS): features

  • Axonal loss
  • Slow conduction velocities
  • Conduction block

Magnetic resonance imaging (MRI)

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Nerve ultrasound

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IgM anti-GM1

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GM1/galactocerebroside complexes (GM1/GalC)

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Other investigations

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References

  1. van der Pol W-L, Cats EA, van den Berg LH. Intravenous immunoglobulin treatment in multifocal motor neuropathy. J Clin Immunol 2010; 30 (Suppl 1):S79-S83.
  2. van Asseldonk JTH, van den Berg LH, Kalmijn S, et al. Axonal loss is an important determinant of weakness in multifocal motor neuropathy. JNNP 2006; 77:743-747.
  3. Rajabally YA. Multifocal motor neuropathy: review of a treatable immune mediated disorder. Postgrad Med J 2008; 84:287-292.
  4. Rattay TW, Winter N, Décard BF, et al. Nerve ultrasound as follow-up tool in treated multifocal motor neuropathy. Eur J Neurol 2017; 24:1125-1134.
  5. Breiner A, Ebadi H, Bril V, Barnett C, Katzberg HD. Ultrasound in multifocal motor neuropathy: clinical and electrophysiological correlations. J Clin Neuromuscul Dis 2019; 20:165-172.
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