Multifocal motor neuropathy (MMN): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Multifocal motor neuropathy (MMN): clinical features. Upper limb onset weakness, Wrist drop, Weak grip, Foot drop. Fully referenced neurology checklist.
Main clinical features
- Upper limb onset weakness
- Wrist drop
- Weak grip
- Foot drop
- Frequent cramps
- Twitching
- Differential finger extension weakness
- Cold paresis: weakness is worse in the cold
Rarer clinical features
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Reported MMN risk factors
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Monofocal motor neuropathy variant
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Differential diagnosis: motor neurone disease (MND)
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Differential diagnosis: others
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References
- Willison H, Mills K. Multifocal motor neuropathy. Pract Neurol 2002; 2:298-301.
- Van Asseldonk JTH, Franssen H, Van den Berg-Vos RM, et al. Multifocal motor neuropathy. Lancet Neurol 2005; 4:309-319.
- Rajabally YA. Multifocal motor neuropathy: review of a treatable immune mediated disorder. Postgrad Med J 2008; 84:287-292.
- Slee M, Selvan A, Donaghy M. Multifocal motor neuropathy: the diagnostic spectrum and response to treatment. Neurology 2007; 69:1680-1687.
- Ivanovski T, Miralles F. Differential weakness of finger extensor muscles: a clinical pattern of multifocal motor neuropathy. Muscle Nerve 2017; 55:433-437.
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