Mononeuropathy multiplex: causes

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Mononeuropathy multiplex: causes. Polyarteritis nodosa (PAN), Granulomatosis with polyangiitis (GPA). Fully referenced neurology checklist.

Primary vasculitic causes

  • Polyarteritis nodosa (PAN)
  • Granulomatosis with polyangiitis (GPA)
  • Eosinophilic granulomatosis with polyangiitis (EGPA)
  • Cryoglobulinaemia
  • Microscopic polyangiitis
  • Henoch-Schonlein purpura
  • Sjogren’s syndrome
  • Giant cell arteritis (GCA)
  • Behcet’s disease
  • Systemic lupus erythematosus (SLE)
  • Rheumatoid vasculitis
  • Primary livedoid vasculopathy
  • Neurosarcoidosis

Infective and inflammatory causes

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Malignant causes

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Drug-induced

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Primary neuromuscular disorders

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Other causes

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Synonym

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References

  1. Rolak LA. Neurology Secrets Third edition. Hanley and Belfus Philadelphia 2001 p86.
  2. Finsterer J. Systemic and non-systemic vasculitis affecting the peripheral nerves. Acta Neurol Belg 2009; 109:100-113.
  3. Alam MA, Hossain MI, Khan AH, Arafat SM. A case of eosinophilic granulomatosis with polyangiitis presenting with mononeuritis multiplex. Curr Rheumatol Rev 2022; 18:368-372.
  4. Feigal DW, Robbins DL, Leek JC. Giant cell arteritis associated with mononeuritis multiplex and complement-activating 19S IgM rheumatoid factor. Am J Med 1985; 79:495-500.
  5. Takeuchi A, Kodama M, Takatsu M, Hashimoto T, Miyashita H. Mononeuritis multiplex in incomplete Behcet's disease: a case report and the review of the literature. Clin Rheumatol 1989; 8:375-380.
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