Methotrexate
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Methotrexate. Use Folic acid 5mg daily 6 days a week, Avoid Folic acid on the days Methotrexate is taken. Fully referenced neurology checklist.
Precautions
- Use Folic acid 5mg daily 6 days a week
- Avoid Folic acid on the days Methotrexate is taken
- Institute male and female contraception
- Continue contraception for 3 months after stopping treatment
- Avoid live vaccines
- Annual influenza vaccinations
- Avoid excessive sun exposure
Contraindications
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Baseline assessments
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Assessments if chest X ray or TLCO are abnormal
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Other assessments: liver biopsy
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Monitoring blood tests
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Monitoring frequency
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Treatment of toxicity
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Indications for stopping
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References
- Chakravarty K, McDonald H, Pullar T, et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatology 2008; 47:924-925.
- Ledingham J, Gullick N, Irving K, et al. BSR and BHPR guideline for the prescription and monitoring of non-biologic disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) 2017; 56:865-868.
- Amato AA, Russell JA. Neuromuscular Disorders. McGraw Hill New York 2008 p711.
