Manganism
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Manganism. This results from manganese toxicity. Fully referenced neurology checklist.
Pathology
- This results from manganese toxicity
- There is elevated manganese in the serum and cerebrospinal fluid (CSF)
Genetic causes
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Acquired causes
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Manganese-associated disorders
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Clinical features: movement disorders
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Clinical features: others
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Differential diagnosis
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Magnetic resonance imaging (MRI) brain: features
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DaT scan
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Treatment
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References
- Budinger D, Barral S, Soo AKS, Kurian MA. The role of manganese dysregulation in neurological disease: emerging evidence. Lancet Neurol 2021; 20:956-968.
- Proudfoot O. Manganese in manganism, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease: A narrative review. Neurol India 2017; 65:1241-1247.
- Ghosh R, Dubey S, Chatterjee S, Ghosh M, Ray BK, Benito-León J. Hypermanganesemia induced chorea and cognitive decline in a tea seller. Tremor Other Hyperkinet Mov (N Y) 2020; 10:45.
- Kulshreshtha D, Ganguly J, Jog M. Manganese and movement disorders: a review. J Mov Disord 2021; 14:93-102.
- Alikunju M, Misiriyyah N, Sayeed Iqbal S, Khan M. Manganese neurotoxicity as a stroke mimic: a case report. Cureus 2023; 15:e37247.
