Malignant hyperthermia (MH): management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Malignant hyperthermia (MH): management. Lactic acid: this is increased. Fully referenced neurology checklist.
Basic investigations
- Lactic acid: this is increased
- Creatinine kinase (CK): this is frequently >10,000 iu/L
- Urinalysis: for myoglobinuria
- Renal function test: especially potassium
Magnetic resonance imaging (MRI) muscle
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In-vitro contracture test (IVCT): types
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Prevention of exertional rhabdomyolysis
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Acute treatment
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Anaesthetic management
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References
- Jurkatt-Rott K, Lerche H, Lehmann-Horn F. Skeletal muscle channelopathies. J Neurol 2002; 249:1493-1502.
- Munhoz RP, Moscovich M, Araujo PD, Tieve HAG. Movement disorders emergencies: a review. Arq Neuropsiquiatr 2012; 70:453-461.
- Heytens K, De Bleecker J, Verbrugghe W, Baets J, Heytens L. Exertional rhabdomyolysis and heat stroke: Beware of volatile anesthetic sedation. World J Crit Care Med 2017; 6:21-27.
- Bharucha-Goebel DX, Santi M, Medne L, et al. Severe congenital RYR1-associated myopathy: the expanding clinicopathologic and genetic spectrum. Neurology 2013; 80:1584-1589.
- Klingler W, Heiderich S, Girard T, et al. Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study. Orphanet J Rare Dis 2014; 9:8.
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