Lyme neuroborreliosis: investigations
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lyme neuroborreliosis: investigations. Seroconversion: this is a 4X rise of anti-Borrelia burgdorferi antibodies. Fully referenced neurology checklist.
Serology
- Seroconversion: this is a 4X rise of anti-Borrelia burgdorferi antibodies
Microbiology
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Cerebrospinal fluid (CSF) analysis
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Magnetic resonance imaging (MRI): common features
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Magnetic resonance imaging (MRI): rare features
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References
- Prasad A, Sankar D. Overdiagnosis and overtreatment of Lyme neuroborreliosis are preventable. Postgrad Med J 1999; 75:650-656.
- Djukic M, Schmidt-Samoa C, Lange P, Spreer A, Neubieser K, Eiffert H, Nau R, Schmidt H. Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis. J Neurol 2012; 259:630-636.
- Pietikäinen A, Oksi J, Hytönen J. Point-of-care testing for CXCL13 in Lyme neuroborreliosis. Diagn Microbiol Infect Dis 2018; pii: S0732-8893(18)30072-5.
- Henningsson AJ, Gyllemark P, Lager M, Skogman BH, Tjernberg I. Evaluation of two assays for CXCL13 analysis in cerebrospinal fluid for laboratory diagnosis of Lyme neuroborreliosis. APMIS 2016; 124:985-990.
- Barstad B, Tveitnes D, Noraas S, et al. Cerebrospinal fluid B-lymphocyte chemoattractant CXCL13 in the diagnosis of acute lyme neuroborreliosis in children. Pediatr Infect Dis J. 2017 Dec;36(12):e286-e292.
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