Lhermitte Duclos disease (LDD)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lhermitte Duclos disease (LDD). This is a dysplastic gangliocytoma of the cerebellum. It is a complex hamartoma. Fully referenced neurology checklist.
Pathology
- This is a dysplastic gangliocytoma of the cerebellum
- It is a complex hamartoma
- It may be bilateral
Pathological features
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Associated disorders
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Clinical features
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Magnetic resonance imaging (MRI)
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Magnetic resonance spectroscopy (MRS)
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Positron emission tomography (PET) scan
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Treatment
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References
- Somagawa C, Ono T, Honda R, et al. Frequent vomiting attacks in a patient with Lhermitte-Duclos disease: a rare pathophysiology of cerebellar lesions? J Neurosurg Pediatr 2017; 20:298-301.
- Andres RH, Guzman R, Weis J, Brekenfeld C, Fandino J, Seiler RW. Lhermitte-Duclos disease with atypical vascularization-case report and review of the literature. Clin Neuropathol 2009; 28:83-90.
- Bozbuga M, Gulec I, Suslu HT, Bayindir C. Bilateral Lhermitte-Duclos disease. Neurol India 2010; 58:309-311.
- Yağci-Küpeli B, Oguz KK, Bilen MA, Yalçin B, Akalan N, Büyükpamukçu M. An unusual cause of posterior fossa mass: Lhermitte-Duclos disease. J Neurol Sci 2010; 290:138-141.
- Dutta G, Singh D, Saran RK, Singh H, Srivastava AK, Jagetia A. Childhood Lhermitte-Duclos disease progressing to medulloblastoma in bilateral cerebellar hemispheres: report of unusual case. World Neurosurg 2018; 117:344-349.
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