Levetiracetam: adverse effects
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Levetiracetam: adverse effects. There is a 0.7% risk of major congenital malformation (MCM). Fully referenced neurology checklist.
Teratogenicity
- There is a 0.7% risk of major congenital malformation (MCM)
- The risk is higher with concomitant Valproate or Carbamazepine
- The risk is less with concomitant Lamotrigine
Neuropsychiatric adverse events (NSAEs)
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Neurological side effects
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Systemic side effects
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References
- Abou-Khalil B. Levetiracetam in the treatment of epilepsy. Neuropsychiatr Dis Treat 2008; 4:507-523.
- Mawhinney E, Craig J, Morrow J, et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology 2013; 80:400-405.
- Fujikawa M, Kishimoto Y, Kakisaka Y, et al. Obsessive-compulsive behavior induced by levetiracetam. J Child Neurol 2015; 30:942-944.
- Chen Z, Lusicic A, O'Brien TJ, Velakoulis D, Adams SJ, Kwan P. Psychotic disorders induced by antiepileptic drugs in people with epilepsy. Brain 2016; 139:2668-2678.
- Molokwu OA, Ezeala-Adikaibe BA, Onwuekwe IO. Levetiracetam-induced rage and suicidality: two case reports and review of literature. Epilepsy Behav Case Rep 2015; 4:79-81.
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