Lambert Eaton myasthenic syndrome (LEMS): antibodies
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lambert Eaton myasthenic syndrome (LEMS): antibodies. This is the most important antibody for the diagnosis of LEMS. Fully referenced neurology checklist.
P/Q type VGCC antibody
- This is the most important antibody for the diagnosis of LEMS
- It is present in 75-100% of paraneoplastic LEMS
- It is present in >90% of non-paraneoplastic LEMS
- It however has a low specificity with a high false positive rate
N type VGCC antibodies
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Anti SOX1 antibody
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Anti GRP78 antibody
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Acronym
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References
- Mantegazza R, Meisel A, Sieb JP, Le Masson G, Desnuelle C, Essing M. The European LEMS Registry: baseline demographics and treatment approaches. Neurol Ther 2015; 4:105-124.
- Lennon VA, Kryzer TJ, Griesmann GE, et al. Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N Engl J Med 1995; 332:1467-1474.
- Martin-Moutot N, de Haro L, Seagar M. Dosage and specificity of anti-calcium channel antibodies in Lambert-Eaton myasthenic syndrome. Rev Neurol (Paris) 2004; 160:S28-S34.
- Sabater L, Titulaer M, Saiz A, Verschuuren J, Gure AO, Graus F. SOX1 antibodies are makers of paraneoplastic Lambert-Eaton myasthenic syndrome. Neurology 2008; 70:924-928.
- Gilhus NE. Lambert-eaton myasthenic syndrome; pathogenesis, diagnosis, and therapy. Autoimmune Dis 2011; 2011:973808.
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