Lafora body disease: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Lafora body disease: clinical features. The onset age is usually 12-17 years: the range is 6-22 years. Fully referenced neurology checklist.
Onset
- The onset age is usually 12-17 years: the range is 6-22 years
- Onset after the age of 50 years has been reported
Seizure types
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Psychiatric features
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Cognitive features
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Other features
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Clinical course
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Differential diagnosis (of progressive myoclonus epilepsy)
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References
- Chan EM, Omer S, Ahmed M, et al. Progressive myoclonus epilepsy with polyglucosans (Lafora disease): evidence for a third locus. Neurology 2004; 63:565-567.
- Lohi H, Turnbull J, Zhao XC, et al. Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. Neurology 2007; 68:996-1001.
- Franceschetti S, Michelucci R, Canafoglia L, et al. Progressive myoclonic epilepsies: definitive and still undetermined causes. Neurology 2014; 82:405-411.
- Andrade DM, Turnbull J, Minassian BA. Lafora disease, seizures and sugars. Acta Myol 2007; 26:83-86.
- Turnbull J, Girard JM, Lohi H, et al. Early-onset Lafora body disease. Brain 2012; 135:2684-2698.
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