Interferons
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Interferons. Interferons inhibit the migration of B cells into the central nervous system. Fully referenced neurology checklist.
Mode of action
- Interferons inhibit the migration of B cells into the central nervous system
- They induce interleukin 10 and 14 (IL-10 and IL-4)
- They also inhibit pro-inflammatory cytokines e.g. IL-17
Dosing
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Pegylated interferon (PEG interferon) β1a
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Precaution
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Drug-related side effects
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Systemic side effects
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Neurological side effects
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PEG interferon side effects
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Monitoring of interferon treatment: indices
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Monitoring of interferon treatment: frequency
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Precautions
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Treatment of injection-site reactions
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Acronyms
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References
- Torkildsen Ø, Myhr KM, Bø L. Disease-modifying treatments for multiple sclerosis – a review of approved medications. Eur J Neurol 2016; 23(Suppl 1):18-27.
- Rejdak K, Jackson S, Giovannoni G. Multiple sclerosis: a practical overview for clinicians. Br Med Bull 2010; 95:79-104.
- Rice CM. Disease modification in multiple sclerosis: an update. Pract Neurol 2014; 14:6-13.
- Dargahi N, Katsara M, Tselios T, et al. Multiple sclerosis: immunopathology and treatment update. Brain Sci 2017; 7(7) pii: E78.
- Wingerchuk DM, Weinshenker BG. Disease modifying therapies for relapsing multiple sclerosis. BMJ 2016; 354:i3518.
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