Inflammatory bowel disease (IBD): neurological features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Inflammatory bowel disease (IBD): neurological features. Immune mediated damage, Brain-gut axis dysfunction. Fully referenced neurology checklist.
Pathophysiological mechanisms
- Immune mediated damage
- Brain-gut axis dysfunction
- Thromboembolism: arterial and venous
- Infections
- Nutritional deficiencies
- Anti-TNF-α side effects:
- Other medication side effects
CNS demyelination
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Vascular features
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Other central neurological features
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Peripheral nerve features
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Muscle features
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Psychiatric features
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Acronym
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References
- Ferro JM, Oliveira Santos M. Neurology of inflammatory bowel disease. J Neurol Sci 2021; 424:117426.
- Morís G. Inflammatory bowel disease: an increased risk factor for neurologic complications. World J Gastroenterol 2014; 20:1228-1237.
- De Felice KM, Novotna M, Enders FT, et al. Idiopathic inflammatory demyelinating disease of the central nervous system in patients with inflammatory bowel disease: retrospective analysis of 9095 patients. Aliment Pharmacol Ther 2015; 41:99-107.
- Cortese R, Prosperini L, Stasolla A, et al. Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy. J Neurol 2021; 268:2895-2899.
- Kunchok A, Aksamit AJ Jr, Davis JM 3rd, et al. Association between tumor necrosis factor inhibitor exposure and inflammatory central nervous system events. JAMA Neurol 2020; 77:937-946.
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