Huntington’s disease (HD): treatment
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Huntington’s disease (HD): treatment. Tetrabenazine, Deutetrabenazine, Valbenazine. Fully referenced neurology checklist.
Treatments of chorea: VMAT blockers
- Tetrabenazine
- Deutetrabenazine
- Valbenazine
Treatments of chorea: Neuroleptics
Locked: subscribe to see this section.
Treatments of chorea: other agents
Locked: subscribe to see this section.
Treatments of depression
Locked: subscribe to see this section.
Treatments of altered sleep-wake cycle
Locked: subscribe to see this section.
Mood stabilisers
Locked: subscribe to see this section.
Physical exercise
Locked: subscribe to see this section.
Investigational treatments
Locked: subscribe to see this section.
Acronym
Locked: subscribe to see this section.
References
- Armstrong MJ, Miyasaki JN. Evidence-based guideline: pharmacologic treatment of chorea in Huntington disease. Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2012; 79:597–603.
- Novak MJU, Sarah J Tabrizi SJ. Huntington’s disease. BMJ 2010; 340:c3109.
- Huntington Study Group, Frank S, Testa CM, Stamler D, et al. Effect of deutetrabenazine on chorea among patients with Huntington disease. JAMA 2016; 316:40-50.
- Frank S, Stamler D, Kayson E, et al; Huntington Study Group/Alternatives for Reducing Chorea in Huntington Disease Investigators. Safety of converting from tetrabenazine to deutetrabenazine for the treatment of chorea. JAMA Neurol 2017; doi: 10.1001/jamaneurol.2017.1352 (Epub ahead of print).
- Dean M, Sung VW. Review of deutetrabenazine: a novel treatment for chorea associated with Huntington's disease. Drug Des Devel Ther 2018; 12:313-319.
- And 9 more. Subscribe to see the full list
