Hereditary spastic paraplegia type 89 (SPG89)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Hereditary spastic paraplegia type 89 (SPG89). This is caused by mutations in the AMFR gene. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in the AMFR gene
  • The gene is on chromosome 16
  • The transmission is autosomal recessive

Neurological features

Locked: subscribe to see this section.

Magnetic resonance imaging (MRI) brain

Locked: subscribe to see this section.

References

  1. Deng R, Medico-Salsench E, Nikoncuk A, et al. AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Acta Neuropathol 2023; 146:353-368.

Related checklists

Loading...