Hereditary spastic paraplegia (HSP): differential diagnosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Hereditary spastic paraplegia (HSP): differential diagnosis. Dopa-responsive dystonia (DRD). Fully referenced neurology checklist.
Neurodegenerative differentials
- Dopa-responsive dystonia (DRD)
- Motor neurone disease (MND): primary lateral sclerosis (PLS)
- Spinocerebellar ataxia (SCA)
- Friedreich’s ataxia (FA)
Inflammatory and infective differentials
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Nutritional and metabolic differentials
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Structural and vascular differentials
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Other differentials
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Terminology
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References
- Salinas S, Proukakis C, Crosby A, Warner TT. Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms. Lancet Neurol 2008; 7:1127-1138.
- Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol 2007; 6:903-912.
- Warner T. Hereditary spastic paraplegia. ACNR 2007; 6: 16-17.
- Hensiek A, Kirker S, Reid E. Diagnosis, investigation and management of hereditary spastic paraplegias in the era of next-generation sequencing. J Neurol 2015; 262:1601-1612.
- Fukushima T, Shirota M, Waragai M, et al. Spinal endoscopic biopsy in the diagnosis of central nervous system neurosarcoidosis. JNNP 2006; 77:702.
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