Hepatitis E virus (HEV) neurology

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Hepatitis E virus (HEV) neurology. Genotypes 1 and 2: this is endemic in the developing world. Fully referenced neurology checklist.

Virology

  • Genotypes 1 and 2: this is endemic in the developing world
  • Genotypes 3 and 4: this is a porcine zoonosis in the developed world

Transmission

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Pathogenesis of neurological involvement

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Neuralgic amyotrophy (brachial neuritis)

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Other peripheral neurological features

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Central neurological features

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Systemic features

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Infective differential diagnoses

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Investigations

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Treatment of neuralgic amyotrophy

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References

  1. Kamar N, Bendall RP, Peron JM, et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis 2011; 17:173-179.
  2. Cheung MC, Maguire J, Carey I, Wendon J, Agarwal K. Review of the neurological manifestations of hepatitis E infection. Ann Hepatol 2012; 11:618-622.
  3. Dalton HR, Kamar N, van Eijk JJ, et al. Hepatitis E virus and neurological injury. Nat Rev Neurol 2016; 12:77-85. 
  4. Mclean BN, Gulliver J, Dalton HR. Hepatitis E virus and neurological disorders. Pract Neurol 2017; 17:282-288.
  5. Abravanel F, Pique J, Couturier E, et al; HEV study group. Acute hepatitis E in French patients and neurological manifestations. J Infect 2018; pii: S0163-4453(18)30185-3. 
  6. And 17 more. Subscribe to see the full list

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