Granulomatosis with polyangiitis (GPA): neurological features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Granulomatosis with polyangiitis (GPA): neurological features. Central diabetes insipidus, Central hypothyroidism. Fully referenced neurology checklist.

Pituitary abnormalities

  • Central diabetes insipidus
  • Central hypothyroidism
  • Secondary adrenal insufficiency
  • Growth hormone deficiency
  • Hyperprolactinemia
  • Hypogonadotropic hypogonadism
  • Lymphocytic pituitiritis

Hypertrophic pachymeningitis

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Other neurological features

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Synonym

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References

  1. Esposito D, Trimpou P, Giugliano D, Dehlin M, Ragnarsson O. Pituitary dysfunction in granulomatosis with polyangiitis. Pituitary 2017; 20:594-601.
  2. Gu Y, Sun X, Peng M, Zhang T, Shi J, Mao J. Pituitary involvement in patients with granulomatosis with polyangiitis: case series and literature review. Rheumatol Int 2019; 39:1467-1476.
  3. Zhang X, Xing B, You H, Wu H, Zhong Y, Ma J. Severe ophthalmic manifestation in pituitary-involved granulomatosis with polyangiitis: a case report and literature review. BMC Ophthalmol 2018; 18:299.
  4. Arnaoutoglou MA, Xerras CG, Kalevrosoglou IK, Rafailidis VD, Notas KP, Tegos TI. Headache linked to intracranial hypertension and hypertrophic pachymeningitis as the initial and dominant presentation of granulomatosis with polyangiitis. Case report and review of the recent literature. Headache 2018; 58:589-595.
  5. Choi HA, Lee MJ, Chung CS. Characteristics of hypertrophic pachymeningitis in patients with granulomatosis with polyangiitis. J Neurol 2017; 264:724-732.
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