Gomez-Lopez Hernandez syndrome (GLHS)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Gomez-Lopez Hernandez syndrome (GLHS). Bilateral parietal or parieto-occipital alopecia, Trigeminal anaesthesia. Fully referenced neurology checklist.
Diagnostic triad
- Bilateral parietal or parieto-occipital alopecia
- Rhombencephalosynapsis (RES): this is absence of the cerebellar vermis
- Trigeminal anaesthesia
Clinical features
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Magnetic resonance imaging (MRI) brain: features
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Synonym
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References
- Kronlage C, Healy DG. Mystery Case: Bilateral alopecia as clue to diagnosis of Gomez-Lopez-Hernandez syndrome in a 38-year-old man. Neurology 2019; 93:408-410.
- Saricam MH, Tekin B, Unver O, Ekinci G, Ergun T. Gómez-López-Hernández syndrome: a rare cause of bilateral nonscarring alopecia. Pediatr Dermatol 2015; 32:e251-e254.
- Sukhudyan B, Jaladyan V, Melikyan G, Schlump JU, Boltshauser E, Poretti A. Gómez-López-Hernández syndrome: reappraisal of the diagnostic criteria. Eur J Pediatr 2010; 169:1523-1528.
- Perrone E, Burlin S, D'Almeida V, et al. Teaching NeuroImages: Trigeminal ganglia hypoplasia as imaging clue for the diagnosis of Gómez-López-Hernández syndrome. Neurology 2021; 96:e1593-e1594.
