Familial TTR amyloid polyneuropathy (FAP TTR): differential diagnosis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Familial TTR amyloid polyneuropathy (FAP TTR): differential diagnosis. This is the commonest misdiagnosis of FAP. Fully referenced neurology checklist.
CIDP
- This is the commonest misdiagnosis of FAP
- FAP may fulfil the criteria for CIDP
- Marked axonal loss may differentiate FAP from CIDP
- Consider FAP if CIDP is not responding to treatment
Other FAP types
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Other hereditary neuropathies
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Other neuropathies
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Other differentials
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Acronym
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References
- Adams D, Suhr OB, Hund E, et al; European Network for TTR-FAP (ATTReuNET). First European consensus for diagnosis, management, and treatment of transthyretin familial amyloid polyneuropathy. Curr Opin Neurol 2016; 29(Suppl 1):S14-S26.
- Lozeron P, Mariani LL, Dodet P, et al. Transthyretin amyloid polyneuropathies mimicking a demyelinating polyneuropathy. Neurology 2018; 91:e143-e152.
- Plante-Bordeneuve V, Ferreira A, Lalu T, et al. Diagnostic pitfalls in sporadic transthyretin familial amyloid polyneuropathy (TTR-FAP). Neurology 2007; 69:693-698.
- Mathis S, Magy L, Diallo L, Boukhris S, Vallat JM. Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 2012; 45:26-31.
