Early neurological deterioration (END)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Early neurological deterioration (END). Severe stroke: involving >33% of the MCA territory, Large vessel occlusion. Fully referenced neurology checklist.
Stroke-related predictors
- Severe stroke: involving >33% of the MCA territory
- Large vessel occlusion
- Hyperdense MCA sign
- Proximal arterial occlusion
- Lack of recanalization
- Previous transient ischaemic attacks (TIAs)
- Intracranial haemorrhage (ICH)
- Transient ischemic attack without identified lesion
Patient-related predictors
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Neurological predictors
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Medical predictors
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Investigational treatment
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Acronym
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References
- Thanvi B, Treadwell S, Robinson T. Early neurological deterioration in acute ischaemic stroke: predictors, mechanisms and management. Postgrad Med J 2008; 84:412-417.
- Seners P, Turc G, Oppenheim C, Baron JC. Incidence, causes and predictors of neurological deterioration occurring within 24 h following acute ischaemic stroke: a systematic review with pathophysiological implications. JNNP 2015; 86:87-94.
- Park TH, Lee JK, Park MS, et al. Neurological deterioration in patients with acute ischemic stroke or transient ischemic attack. Neurology 2020 (Online ahead of print).
- Nam KW, Kwon HM, Park SW, Lim JS, Han MK, Lee YS. Distal hyperintense vessel sign is associated with neurological deterioration in acute ischaemic stroke. Eur J Neurol 2017; 24:617-623.
- Ford AL, An H, D'Angelo G, et al. Preexisting statin use is associated with greater reperfusion in hyperacute ischemic stroke. Stroke 2011; 42:1307-2313.
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