DYT3: X-linked dystonia (Lubag)

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

DYT3: X-linked dystonia (Lubag). This is caused by mutations in the TAF1 gene. The transmission is X-linked. Fully referenced neurology checklist.

Genetics

  • This is caused by mutations in the TAF1 gene
  • The transmission is X-linked

Clinical features

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Associated movement disorders

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Psychiatric features

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Differential diagnosis

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Magnetic resonance imaging (MRI) brain

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Treatment

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References

  1. Muller U. The monogenic primary dystonias. Brain 2009; 132:2005-2025.
  2. Albanese A, Asmus F, Bhatia KP, et al. EFNS guidelines on diagnosis and treatment of primary dystonias. Eur J Neurol 2011; 18:5-18. 
  3. Ledoux MS, Dauer WT, Warner TT. Emerging common molecular pathways for primary dystonia. Mov Disord 2013; 28:968-981.
  4. Müller U. The monogenic primary dystonias. Brain 2009; 132:2005-2025.
  5. Evidente VG, Advincula J, Esteban R, et al. Phenomenology of "Lubag" or X-linked dystonia-parkinsonism. Mov Disord 2002; 17:1271-1277.
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