Duchenne muscular dystrophy (DMD): steroid management

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Duchenne muscular dystrophy (DMD): steroid management. Steroids are gold standard. Fully referenced neurology checklist.

Indications and use

  • Steroids are gold standard
  • They are indicated from the age of 5 years
  • They are administered even in non-ambulant subjects

Benefits

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Steroid regimes

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Vamorolone

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Steroid monitoring indices: symptoms

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Steroid monitoring indices: assessments

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Management of steroid adverse effects

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References

  1. Araujo APQC, Saute JAM, Fortes CPDD, et al. Update of the Brazilian consensus recommendations on Duchenne muscular dystrophy. Arq Neuropsiquiatr 2023; 81:81-94.
  2. Bushby K, Muntoni F, Urtizberea A, Hughes R, Griggs R. Report of the 124th ENMC International Workshop. Treatment of Duchenne muscular dystrophy; defining the gold standards of management in the use of corticosteroids 2-4 April 2004, Naarden, The Netherlands. Neuromuscul Disord 2004; 14:526-534.
  3. Bushby K, Finkel R, Birnkrant DJ, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurol 2010; 9:77-93.
  4. Bushby K, Muntoni F, Urtizberea A, Hughes R, Griggs R. Report of the 124th ENMC International Workshop. Treatment of Duchenne muscular dystrophy; defining the gold standards of management in the use of corticosteroids 2-4 April 2004, Naarden, The Netherlands. Neuromuscul Disord 2004; 14:526-534.
  5. Gloss D, Moxley RT 3rd, Ashwal S, Oskoui M. Practice guideline update summary: corticosteroid treatment of Duchenne muscular dystrophy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2016; 86:465-472.
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