Duane retraction syndrome (DRS): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Duane retraction syndrome (DRS): clinical features. This is caused by mutations in the DURS2 gene on chromosome 2 in 10% of families. It may be sporadic.
Causes
- This is caused by mutations in the DURS2 gene on chromosome 2 in 10% of families
- It may be sporadic
Clinical features
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References
- Demer JL, Clark RA, Lim KH, Engle EC. Magnetic resonance imaging evidence for widespread orbital dysinnervation in dominant Duane's retraction syndrome linked to the DURS2 locus. Invest Ophthalmol Vis Sci 2007; 48:194-202.
- Yonghong J, Kanxing Z, Zhenchang W, et al. Detailed magnetic resonance imaging findings of the ocular motor nerves in Duane's retraction syndrome. J Pediatr Ophthalmol Strabismus 2009; 46:278-285.
- Xia S, Li RL, Li YP, Qian XH, Chong V, Qi J. MRI findings in Duane's ocular retraction syndrome. Clin Radiol 2014; 69:e191-e198.
- Miyake N, Chilton J, Psatha M, et al. Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome. Science 2008; 321:839-843.
