Distal hereditary motor neuropathy (dHMN): types

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Distal hereditary motor neuropathy (dHMN): types. This is caused by mutations in the HSPB1 and HSPB8 genes. Fully referenced neurology checklist.

dHMN type I

  • This is caused by mutations in the HSPB1 and HSPB8 genes
  • The transmission is autosomal dominant
  • The onset age is juvenile
  • It presents with distal leg involvement

dHMN type II

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dHMN type III

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dHMN type IV

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dHMN type V

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dHMN type VI

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dHMN type VII

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Other dHMN types

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References

  1. Irobi J, De Jonghe P, Timmerman V. Molecular genetics of distal hereditary motor neuropathies. Hum Mol Genet 2004; 13:R195-R202.
  2. Rossor AM, Kalmar B, Greensmith L, Reilly MM. The distal hereditary motor neuropathies. JNNP 2012; 83:6-14.

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