Dilated perivascular spaces (PVS): clinical associations

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Dilated perivascular spaces (PVS): clinical associations. They are seen in healthy people and with older age. Fully referenced neurology checklist.

Physiological associations

  • They are seen in healthy people and with older age
  • These are especially around the anterior commissure and the vertex

Vascular associations

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Cognitive associations

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Neuroinflammatory associations

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Other neurological associations

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Systemic associations

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Synonyms

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Acronyms

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References

  1. Sankararaman S, Velayuthan S, Ambekar S, Gonzalez-Toledo E. Giant tumefactive perivascular spaces: a further case. J Pediatr Neurosci 2013; 8:108-110.
  2. Groeschel S, Chong WK, Surtees R, Hanefeld F. Virchow-Robin spaces on magnetic resonance images: normative data, their dilatation, and a review of the literature. Neuroradiology 2006; 48:745-754.
  3. Francis F, Ballerini L, Wardlaw JM. Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: a systematic review and meta-analysis. Int J Stroke 2019; 14:359-371.
  4. Maclullich AM, Wardlaw JM, Ferguson KJ, Starr JM, Seckl JR, Deary IJ. Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. JNNP 2004; 75:1519-1523.
  5. van Veluw SJ, Biessels GJ, Bouvy WH, et al. Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces. J Cereb Blood Flow Metab 2016; 36:576-580.
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