Dermatoneuro syndrome (DNS)
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Dermatoneuro syndrome (DNS). This occurs in people with scleromyxoedema (SMX). Fully referenced neurology checklist.
Pathophysiology
- This occurs in people with scleromyxoedema (SMX)
- It may be triggered by COVID 19 infection
- It has also been reported after COVID 19 vaccination
Clinical featues
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Treatment
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References
- Bhoyrul B, Mughal AA, Paulus J, Salamat A, Howarth S. Does dermatoneuro syndrome have a viral aetiology? Clin Exp Dermatol 2016; 41:53-56.
- Fleming KE, Virmani D, Sutton E, Langley R, Corbin J, Pasternak S, Walsh NM. Scleromyxedema and the dermato-neuro syndrome: case report and review of the literature. J Cutan Pathol 2012; 39:508-517.
- Li Y, Wang H, Wang A, Zhao G. Dermato-neuro syndrome after COVID-19 infection in a patient with scleromyxoedema: Previously successful treatment with intravenous immunoglobulins. J Dermatol 2024; 51:140-144.
- Gallo R, Trave I, Cotzia E, Russo R, Parodi A. Dermato-neuro syndrome after COVID-19 vaccination in a patient with scleromyxoedema previously controlled with bortezomib and intravenous immunoglobulins. Acta Derm Venereol 2022; 102:adv00836.
- Liem B, Wali G, Khan S, Ieremia E, Ramasamy K, Thompson A, Sen A. Dermato-neuro syndrome triggered by SARS-CoV-2 vaccination. Pract Neurol 2026; 26:51-54.
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