Creutzfeldt Jakob disease (CJD): treatment

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Creutzfeldt Jakob disease (CJD): treatment. Reduce sensory stimuli: light, noise, touch, movement. Fully referenced neurology checklist.

Palliative treatments

  • Reduce sensory stimuli: light, noise, touch, movement
  • Limit visitor numbers
  • Establish consistent daily routines

Depression

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Delirium: non-drug

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Delirium: drugs

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Seizures

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Pain

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Other treatments

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Failed treatment trials

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Investigational treatments

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References

  1. Price JR, Kheirbek RE. Addressing the unmet needs of patients with rapidly progressive neurological disease: a case report of palliative care in Creutzfeldt-Jakob Disease (CJD). Cureus 2024; 16:e55228.
  2. Jurcau MC, Jurcau A, Diaconu RG, Hogea VO, Nunkoo VS. A systematic review of sporadic creutzfeldt-jakob disease: pathogenesis, diagnosis, and therapeutic attempts. Neurol Int 2024; 16:1039-1065.
  3. Kranitz FJ, Simpson DM. Using non-pharmacological approaches for CJD patient and family support as provided by the CJD foundation and CJD insight. CNS Neurol Disord Drug Targets 2009; 8:372-379.
  4. Miranda LHL, Oliveira AFPH, Carvalho DM, et al. Systematic review of pharmacological management in Creutzfeldt-Jakob disease: no options so far? Arq Neuropsiquiatr 2022; 80:837-844.
  5. Liu F, Lü W, Liu L. New implications for prion diseases therapy and prophylaxis. Front Mol Neurosci 2024; 17:1324702.
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