Clobazam
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Clobazam. Clobazam is a 1,5-benzodiazepine, It activates the GABAA receptor. Fully referenced neurology checklist.
Mode of action
- Clobazam is a 1,5-benzodiazepine
- It activates the GABAA receptor
Indications
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Dosing
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Neurological side effects
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Systemic side effects
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Dermatological side effects
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Other side effects
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Drugs which reduce Clobazam blood levels
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References
- Gauthier AC, Mattson RH. Clobazam: a safe, efficacious, and newly rediscovered therapeutic for epilepsy. CNS Neurosci Ther 2015; 21:543-548.
- National Institute for Health and Clinical Excellence. The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care: pharmacological update of clinical guideline 20. London, Royal College of Physicians (UK): National Clinical Guideline Centre; 2012.
- Silva RC, Montenegro MA, Guerreiro CA, Guerreiro MM. Clobazam as add-on therapy in children with epileptic encephalopathy. Can J Neurol Sci 2006; 33:209-213.
- Conry JA, Ng YT, Kernitsky L, et al; OV-1004 Study Investigators. Stable dosages of clobazam for Lennox-Gastaut syndrome are associated with sustained drop-seizure and total-seizure improvements over 3 years. Epilepsia 2014; 55:558-567.
- Wheless JW, Isojarvi J, Lee D, Drummond R, Benbadis SR. Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience. Epilepsy Behav 2014; 41:47-52.
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