Chronic idiopathic axonal polyneuropathy (CIAP): clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Chronic idiopathic axonal polyneuropathy (CIAP): clinical features. Obesity, Hypertension, Impaired fasting glucose. Fully referenced neurology checklist.
Possible risk factors
- Obesity
- Hypertension
- Impaired fasting glucose
- Low HDL cholesterol
- High triglycerides
- Possible association with HLA-DQA1*05 allele
- CANVAS syndrome: this accounts for 27% of cases
Onset features
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Clinical presentation
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Complications
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Progression
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References
- Visser NA, Vrancken AFJE, van der Schouw YT, van den Berg LH, Notermans NC. Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome. Diabetes Care 2013; 36:817-822.
- Notermans NC, Wokke JHJ, Franssen H, et al. Chronic idiopathic polyneuropathy presenting in middle or old age: a clinical and electrophysiological study of 75 patients. JNNP 1993; 56:1066-1071.
- Hughes RAC, Umapathi T, Gray IA, et al. A controlled investigation of the cause of chronic idiopathic axonal polyneuropathy. Brain 2004; 127:1723-1730.
- Singer MA, Vernino SA, Wolfe GI. Idiopathic neuropathy: new paradigms, new promise. J Peripher Nerv Syst 2012; 17(Suppl 2):43-49.
- Callaghan BC, Xia R, Reynolds E, et al. Association between metabolic syndrome components and polyneuropathy in an obese population. JAMA Neurol 2016; 73:1468-1476.
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