Chagas disease: pathology

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Chagas disease: pathology. This is caused by the parasite Trypanosoma cruzi. Fully referenced neurology checklist.

Biology

  • This is caused by the parasite Trypanosoma cruzi
  • It is transmitted by the faeces of the blood-feeding triatomic bug
  • The trypomastigota invade lymphatic tissue
  • They reach the nervous system via the choroid plexus and cerebrospinal fluid (CSF)

Routes of transmission

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Other affected organs

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Risk factors for re-activation

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Synonym

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References

  1. Dzikowiec M, Góralska K, Błaszkowska J. Neuroinvasions caused by parasites. Ann Parasitol 2017; 63:243–253.
  2. Teixeira AR, Nitz N, Guimaro MC, Gomes C, Santos-Buch CA. Chagas disease. Postgrad Med J 2006; 82:788-798. 
  3. Rassi A Jr, Rassi A, Marcondes de Rezende J. American trypanosomiasis (Chagas disease). Infect Dis Clin North Am 2012; 26:275-291.
  4. Antinori S, Galimberti L, Bianco R, Grande R, Galli M, Corbellino M. Chagas disease in Europe: A review for the internist in the globalized world. Eur J Intern Med 2017; 43:6-15.

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