Cerebellar mutism syndrome (CMS): surgical risk factors

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Cerebellar mutism syndrome (CMS): surgical risk factors. CMS develops in 25% of childhood posterior fossa tumour surgeries.

Epidemiology

  • CMS develops in 25% of childhood posterior fossa tumour surgeries

Subject-related risk factors

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Tumour-related risk factors

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Operative risk factors

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References

  1. Toescu SM, Hettige S, Phipps K, et al. Post-operative paediatric cerebellar mutism syndrome: time to move beyond structural MRI. Childs Nerv Syst 2018; doi: 10.1007/s00381-018-3867-x (Epub ahead of print).
  2. Yang W, Ge M, Zhu K, et al. Male predisposition in cerebellar mutism syndrome: a cohort study. Cerebellum 2023; 22:730-738.
  3. Schmidt S, Kovacs E, Usta D, et al. Cerebellar mutism syndrome after posterior fossa tumor surgery in children-a retrospective single-center study. World Neurosurg 2023; 173:e622-e628.
  4. Di Rocco C, Chieffo D, Frassanito P, Caldarelli M, Massimi L, Tamburrini G. Heralding cerebellar mutism: evidence for pre-surgical language impairment as primary risk factor in posterior fossa surgery. Cerebellum 2011; 10:551-562.
  5. Gora NK, Gupta A, Sinha VD. Cerebellar mutism syndrome following midline posterior fossa tumor resection in children: an institutional experience. J Pediatr Neurosci 2017; 12:313-319. 
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