Calf atrophy

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Calf atrophy. Limb girdle muscular dystrophy (LGMD) types 2B and 1C, Distal spinal muscular atrophy (SMA). Fully referenced neurology checklist.

Neurological causes

  • Limb girdle muscular dystrophy (LGMD) types 2B and 1C
  • Distal spinal muscular atrophy (SMA)
  • Benign monomelic amyotrophy of the lower limb
  • Tethered cord syndrome
  • Intraneural perineuroma

Orthopaedic causes

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References

  1. Katz JS, Rando TA, Barohn RJ, et al. Late-onset distal muscular dystrophy affecting the posterior calves. Muscle Nerve 2003; 28:443-448.
  2. Arias Gómez M, Alberte-Woodwar M, Arias-Rivas S, Dapena D, Pintos E, Navarro C. Unilateral calf atrophy secondary to a de novo mutation of the caveolin-3 gene. Muscle Nerve 2011; 44:126-128. 
  3. Sumner CJ, d'Ydewalle C, Wooley J, et al. A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance. Am J Hum Genet 2013; 93:976-983. 
  4. Felice KJ, Whitaker CH, Grunnet ML. Benign calf amyotrophy: clinicopathologic study of 8 patients. Arch Neurol 2003; 60:1415-1420.
  5. Hamano T, Mutoh T, Hirayama M, et al. MRI findings of benign monomelic amyotrophy of lower limb. J Neurol Sci 1999; 165:184-187.
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