Calcineurin-inhibitor neurotoxicity: pathology and risk factors

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Calcineurin-inhibitor neurotoxicity: pathology and risk factors. Tacrolimus, Ciclosporin. Fully referenced neurology checklist.

Major calcineurin inhibitors

  • Tacrolimus
  • Ciclosporin

Mode of action

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Risk factors

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References

  1. Pruitt AA, Graus F, Rosenfeld MR. Neurological complications of solid organ transplantation. Neurohospitalist 2013; 3:152-166. 
  2. Senzolo M, Ferronato C, Burra P. Neurologic complications after solid organ transplantation. Transpl Int 2009; 22:269-278.
  3. Chang GY, Saadi A, Schmahmann JD. Pearls & Oy-sters: Tacrolimus neurotoxicity presenting as an isolated brainstem lesion. Neurology 2016; 87:1423. 
  4. Anghel D, Tanasescu R, Campeanu A, Lupescu I, Podda G, Bajenaru O. Neurotoxicity of immunosuppressive therapies in organ transplantation. Maedica (Buchar) 2013; 8:170-175. 
  5. Chegounchi M, Hanna MG, Neild GH. Progressive neurological disease induced by tacrolimus in a renal transplant recipient: case presentation. BMC Nephrol 2006; 7:7.
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