CADASIL: management
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
CADASIL: management. High signal changes in the anterior temporal poles, Diffuse white matter high signal changes. Fully referenced neurology checklist.
Magnetic resonance imaging (MRI): features
- High signal changes in the anterior temporal poles
- Diffuse white matter high signal changes
- Microbleeds: these are usually in the thalamus
Cerebrospinal fluid (CSF) analysis
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Genetics
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Other investigations
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Treatment of vasculopathy
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Treatment of migraine
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Acronym
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References
- Adib-Samii P, Brice G, Martin RJ, Markus HS. Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype study in 200 consecutively recruited individuals. Stroke 2010; 41:630-634.
- Oberstein SAJL, van den Boom R, van Buchem MA, et al. Cerebral microbleeds in CADASIL. Neurology 2001; 57:1066.
- Razvi SSM, Muir KW. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Pract Neurol 2004; 4:50-55.
- Pantoni L, Pescini F, Nannucci S, et al. Comparison of clinical, familial, and MRI features of CADASIL and-negative patients NOTCH3. Neurology 2010; 74:57–63.
- Chabriat H, Hervé D, Duering M, et al. Predictors of clinical worsening in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: prospective cohort study. Stroke 2016; 47:4-11.
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