Brain tumours: chemotherapy
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Brain tumours: chemotherapy. This is an alkylating agent. It improves survival when combined with Valproate. Fully referenced neurology checklist.
Temozolomide
- This is an alkylating agent
- It improves survival when combined with Valproate
- Valproate is therefore the antiepileptic drug (AED) of choice
Other alkylating agents
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Bevacizumab
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Everolimus
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Steroids
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Immune checkpoint inhibitors: types
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Investigational immunotherapies
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References
- Grant R. Overview: brain tumour diagnosis and management/Royal College of Physicians guidelines. JNNP 2004; 75:(Suppl II):ii18-ii23.
- Laquintana V, Trapani A, Denora N, Wang F, Gallo JM, Trapani G. New strategies to deliver anticancer drugs to brain tumors. Expert Opin Drug Deliv 2009; 6:1017-1032.
- Armand JP, Ribrag V, Harrousseau JL, Abrey L. Reappraisal of the use of procarbazine in the treatment of lymphomas and brain tumors. Ther Clin Risk Manag 2007; 3:213-224.
- Ansstas G, Tran DD. Treatment with tumor-treating fields therapy and pulse dose bevacizumab in patients with bevacizumab-refractory recurrent glioblastoma: a case series. Case Rep Neurol 2016; 8:1-9.
- Franz DN, Belousova E, Sparagana S, et al. Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study. Lancet Oncol 2014; 15:1513-1520.
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