Anti-seizure medications (ASMs) and hyponatremia
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-seizure medications (ASMs) and hyponatremia. Oxcarbezepine: this occurs in 43-36% of cases. Fully referenced neurology checklist.
AEDS with high risk of hyponatremia
- Oxcarbezepine: this occurs in 43-36% of cases
- Eslicarbazepine: this develops in 33% of cases
- Carbamazepine: this develops in 16-26% of cases
AEDS with medium risk of hyponatremia
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AEDS with low risk of hyponatremia
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Pathogenesis of hyponatraemia with AEDs
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Risk factors for hyponatremia with AEDs
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Symptoms of hyponatremia
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Precautions with Oxcarbazepine and Carbamazepine
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References
- Falhammar H, Lindh JD, Calissendorff J, et al. Differences in associations of antiepileptic drugs and hospitalization due to hyponatremia: a population-based case-control study. Seizure 2018; 59:28-33.
- Berghuis B, van der Palen J, de Haan GJ, Lindhout D, Koeleman BPC, Sander JW; EpiPGX Consortium. Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy. Epilepsia 2017; 58:1227-1233.
- Lin CH, Lu CH, Wang FJ, et al. Risk factors of oxcarbazepine-induced hyponatremia in patients with epilepsy. Clin Neuropharmacol 2010; 33:293-296.
- Intravooth T, Staack AM, Juerges K, Stockinger J, Steinhoff BJ. Antiepileptic drugs-induced hyponatremia: review and analysis of 560 hospitalized patients. Epilepsy Res 2018; 143:7-10.
- Berghuis B, de Haan GJ, van den Broek MP, Sander JW, Lindhout D, Koeleman BP. Epidemiology, pathophysiology and putative genetic basis of carbamazepine- and oxcarbazepine-induced hyponatremia. Eur J Neurol 2016; 23:1393-1399.
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