Anti NMDAR autoimmune encephalitis: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anti NMDAR autoimmune encephalitis: clinical features. Females account for 70-90% of cases. Fully referenced neurology checklist.

Epidemiology

  • The median onset age is about 22 years: the age range is 5-76 years
  • Females account for 70-90% of cases

Triggers

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Encephalitic features

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Movement disorders

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Sleep disorders

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Psychiatric features

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Systemic features

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References

  1. Dalmau J, Glelchman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case serious and analysis of the effects of antibodies. Lancet Neurol 2008; 7:1091-1098.
  2. Irani SR, Bera K, Waters P, et al. N-methyl-D-aspartase antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 2010; 133:1655-1667.
  3. Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 2016; 15:391-404.
  4. Nosadini M, Mohammad SS, Corazza F, et al. Herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases. Dev Med Child Neurol 2017; 59:796-805.
  5. Hacohen Y, Deiva K, Pettingill P, et al. N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. Mov Disord 2014; 29:90-96.
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