Anti-MOG antibody disease (MOGAD): CSF features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti-MOG antibody disease (MOGAD): CSF features. Anti MOG antibody is less frequently detected in CSF than in serum. Fully referenced neurology checklist.
Anti MOG antibody
- Anti MOG antibody is less frequently detected in CSF than in serum
- It may be positive in CSF and negative in serum
- Positive CSF and MOG antibodies predict severer disease and poorer outcome
- Positive CSF anti-MOG is also seen with NMO and ADEM
Other CSF features
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Synonyms
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References
- Jarius S, Ruprecht K, Kleiter I, et al; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation 2016; 13:280.
- Jarius S, Kleiter I, Ruprecht K, et al; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome. J Neuroinflammation 2016; 13:281.
- Aoe S, Kume K, Takata T, et al. Clinical significance of assaying anti-MOG antibody in cerebrospinal fluid in MOG-antibody-associated diseases: a case report. Mult Scler Relat Disord 2019; 28:165-166.
- Mariotto S, Gajofatto A, Batzu L, et al. Relevance of antibodies to myelin oligodendrocyte glycoprotein in CSF of seronegative cases. Neurology 2019; 93:e1867-e1872.
- Carta S, Cobo Calvo Á, Armangué T, et al. Significance of myelin oligodendrocyte glycoprotein antibodies in CSF: a retrospective multicenter study. Neurology 2023; 100:e1095-e1108.
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