Anti LG1 VGKC autoimmune encephalitis: faciobrachial dystonic seizures
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti LG1 VGKC autoimmune encephalitis: faciobrachial dystonic seizures. They start before the onset of encephalitis. Fully referenced neurology checklist.
Presentation
- They start before the onset of encephalitis
- They may present as isolated epilepsy
Clinical features
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Triggers
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Implications
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References
- Lee R, Buckley C, Irani SR, Vincent A. Autoantibody testing in encephalopathies. Pract Neurol 2012; 12:4-13.
- Vincent A, Bien CG, Irani SR, Waters P. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011; 10:759-772.
- Binks SNM, Klein CJ, Waters P, Pittock SJ, Irani SR. LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes. JNNP 2017; pii: jnnp-2017-315720 (Epub ahead of print).
- Rodríguez Cruz PM, Pérez Sánchez JR, Alarcón Morcillo C, Velázquez Pérez JM. Alternating faciobrachial dystonic seizures in LGI1-antibody limbic encephalitis. Pract Neurol 2016; 16:387-388.
- Thompson J, Bi M, Murchison AG, et al; Faciobrachial Dystonic Seizures Study Group. The importance of early immunotherapy in patients with faciobrachial dystonic seizures. Brain 2018; 141:348-356.
