Anti-Hu antibody paraneoplastic syndrome: clinical features

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Anti-Hu antibody paraneoplastic syndrome: clinical features. Limbic encephalitis, Paraneoplastic encephalitis. Fully referenced neurology checklist.

Major syndromes

  • Limbic encephalitis
  • Paraneoplastic encephalitis
  • Paraneoplastic cerebellar degeneration

Movement disorders

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Seizure disorders

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Ophthalmic features

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Cranial neuropathies

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Peripheral neuropathy

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Autonomic dysfunction

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Other clinical features

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Magnetic resonance imaging (MRI) features

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References

  1. Rosenbloom MH, Smith S, Akdal G, Geschwind MD. Immunologically mediated dementias. Curr Neurol Neurosci Rep 2009; 9:359-367.
  2. Graus F, Keime-Guibert F, Reñe R, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 2001; 124:1138-1148.
  3. Hersh B, Dalmau J, Dangond F, Gultekin S, Geller E, Wen PY. Paraneoplastic opsoclonus-myoclonus associated with anti-Hu antibody. Neurology 1994; 44:1754-1755. 
  4. Langer JE, Lopes MB, Fountain NB, et al. An unusual presentation of anti-Hu-associated paraneoplastic limbic encephalitis. Dev Med Child Neurol 2012; 54:863-866.
  5. Schrader C, Alwan G, Weissenborn K. Pseudochoreoathetosis can be the first clinical manifestation of anti-Hu-neuropathy associated with squamous cell carcinoma. Mov Disord 2008; 23:2257-2259.
  6. And 29 more. Subscribe to see the full list

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