Anti GABA-A autoimmune encephalitis
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Anti GABA-A autoimmune encephalitis. Cognitive impairment, Altered consciousness, Abnormal behaviour. Fully referenced neurology checklist.
Clinical features
- Cognitive impairment
- Altered consciousness
- Abnormal behaviour
- Frequent seizures: including refractory and status epilepticus
- Focal neurological deficits
- Opsoclonus myoclonus
Associated disorders
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Magnetic resonance imaging (MRI) brain
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Treatment
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Prognosis
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References
- Hacohen Y, Joseph S, Kneen R, Eunson P, Lin JP, Vincent A, Lim M. Limbic encephalitis associated with elevated antithyroid antibodies. J Child Neurol 2014; 29:769-773.
- Petit-Pedrol M, Armangue T, Peng X, et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol 2014; 13:276-286.
- Spatola M, Petit-Pedrol M, Simabukuro MM, et al. Investigations in GABAA receptor antibody-associated encephalitis. Neurology 2017; 88:1012-1020.
- O'Connor K, Waters P, Komorowski L, et al. GABAA receptor autoimmunity: a multicenter experience. Neurol Neuroimmunol Neuroinflamm 2019; 6:e552.
