Alexander disease: clinical features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Alexander disease: clinical features. Macrocephaly, Spasticity, Ataxia, Psychomotor regression, Seizures. Fully referenced neurology checklist.
Features of infantile-onset
- Macrocephaly
- Spasticity
- Ataxia
- Psychomotor regression
- Seizures
- Infantile spasms
Features of juvenile-onset
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Brainstem features
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Other features
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Rare features
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Differential diagnsois
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Acronym
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References
- Pareyson D, Fancellu R, Mariotti C, et al. Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature. Brain 2008; 131:2321-2331.
- Sreedharan J, Shaw CE, Jarosz J, Samuel M. Alexander disease with hypothermia, microcoria, and psychiatric and endocrine disturbance. Neurology 2007; 68:1322-1323.
- Lee JM, Kim AS, Lee SJ, et al. A case of infantile Alexander disease accompanied by infantile spasms diagnosed by DNA analysis. J Korean Med Sci 2006; 21:954-957.
- Ullah R, Wazir MH, Gul A, Gul F, Arshad A. Juvenile Alexander disease: a rare leukodystrophy. Cureus 2022; 14:e24870.
- Sebesto JR, van Gerpen JA. Teaching Video NeuroImages: palatal tremor in adult-onset Alexander disease. Neurology 2016; 86:e252.
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