Alemtuzumab: clinical use
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Alemtuzumab: clinical use. Alemtuzumab is a humanised anti-CD52 monoclonal antibody. Fully referenced neurology checklist.
Mode of action
- Alemtuzumab is a humanised anti-CD52 monoclonal antibody
- It targets circulating memory cells
- It depletes CD52+ B lymphocytes: especially CD4, natural killer, and B cells
Dosing
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Benefits in MS
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References
- Torkildsen Ø, Myhr KM, Bø L. Disease-modifying treatments for multiple sclerosis–a review of approved medications. Eur J Neurol 2016; 23(Suppl 1):18-27.
- Rice CM. Disease modification in multiple sclerosis: an update. Pract Neurol 2014; 14:6-13.
- Thomas K, Eisele J, Rodriguez-Leal FA, Hainke U, Ziemssen T. Acute effects of alemtuzumab infusion in patients with active relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm 2016; 3:e228.
- Dargahi N, Katsara M, Tselios T, et al. Multiple sclerosis: immunopathology and treatment update. Brain Sci 2017; 7(7) pii: E78.
