Akinetic mutism
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Akinetic mutism. This is caused by disconnection of frontal-cingulate-limbic subcortical circuits. Fully referenced neurology checklist.
Pathology
- This is caused by disconnection of frontal-cingulate-limbic subcortical circuits
- This disrupts the frontal neuronal systems involved with executive functions
- It is usually associated with anterior cingulate lesions
Vascular causes: stroke
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Vascular causes: others
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Neoplastic causes
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Traumatic causes
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Infective causes
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Toxic and drug-induced
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Other neurological causes
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Treatment
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References
- Mega MS, Cohenour RC. Akinetic mutism: disconnection of frontal-subcortical circuits. Neuropsychiatry Neuropsychol Behav Neurol 1997; 10:254-259.
- Németh G, Hegedüs K, Molnár L. Akinetic mutism associated with bicingular lesions: clinicopathological and functional anatomical correlates. Eur Arch Psychiatry Neurol Sci 1988; 237:218-222.
- Tengvar C, Johansson B, Sorensen J. Frontal lobe and cingulate cortical metabolic dysfunction in acquired akinetic mutism: a PET study of the interval form of carbon monoxide poisoning. Brain Inj 2004; 18:615-625.
- Nagaratnam N, Nagaratnam K, Ng K, Diu P. Akinetic mutism following stroke. J Clin Neurosci 2004; 11:25-30.
- Nicolai J, van Putten MJ, Tavy DL. BIPLEDs in akinetic mutism caused by bilateral anterior cerebral artery infarction. Clin Neurophysiol 2001; 112:1726-1728.
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