Adult-onset autosomal dominant leukodystrophy with autonomic symptoms (ADLD): treatment

Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .

Adult-onset autosomal dominant leukodystrophy with autonomic symptoms (ADLD): treatment. Early referral to urology. Fully referenced neurology checklist.

Bladder dysfunction

  • Early referral to urology
  • Fluid restriction at night
  • Avoid bladder irritants
  • Self-catheterisation if post void volume is >100mL
  • Anticholinergic drugs if post void volume is <100mL

Constipation

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Erectile dysfunction

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Postural hypotension

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Spasticity

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References

  1. Dhamija R, Tobin WO, Cortelli P, et al. Clinical practice guidelines for the diagnosis, management, and surveillance of LMNB1-related autosomal dominant leukodystrophy. Neurol Genet 2025; 11:e200287.

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