Adrenoleukodystrophy (ALD): systemic features
Written and reviewed by Dr Ibrahim Imam, Consultant Neurologist. Last reviewed .
Adrenoleukodystrophy (ALD): systemic features. Bronzed skin pigmentation, Scanty hair, Gastrointestinal disturbance. Fully referenced neurology checklist.
Addisonian features
- Bronzed skin pigmentation
- Scanty hair
- Gastrointestinal disturbance
- Fatigue
- Hypotension
- Hyponatraemia
- Impaired synacthen test
- Symptoms may develop before, with, or after neurological symptoms
- They may precede neurological features by years
Other endocrine features
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Features of female heterozygote carriers
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Acronyms
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References
- van Geel BM, Assies J, Wanders RJ, Barth PG. X linked adrenoleukodystrophy: clinical presentation, diagnosis, and therapy. JNNP 1997; 63:4-14.
- Das G, Baglioni P, Kadiyala R. Importance of family history in patients with adrenoleukodystrophy QJM 2010; 103:628-630.
- Engelen M, Barbier M, Dijkstra IM, et al. X-linked adrenoleukodystrophy in women: a cross-sectional cohort study. Brain 2014; 137:693-706.
